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TAM signaling is activated at the interface of the innate and adaptive immune response. (1) TLR signaling triggers the activation of DCs and the induction of TAM receptors. (2) Activated DCs present antigen to T cells and induce the exposure of PtdSer and the expression of the TAM agonist Pros1 on activated T cells. (3) T cell-derived Pros1 activates the TAM receptors on DCs to limit the magnitude of the DC response.
