Table 2.
List of miRNAs and lncRNAs associated with breast cancer stem cells (CSCs).
| ncRNAs | Source | Function | Signaling upstream | Signaling downstream | Target genes | Reference |
|---|---|---|---|---|---|---|
| Let-7 | lin/CD44+/CD24- (SK-3rd) Human | Inhibition of self-renewal | H-RAS and HMGA2 | Yu et al. (2007) | ||
| Let-7 | Human breast cells transformed with Src (MCF10A ER-SRC) | Inhibition of cell transformation | SRC/IL-6/NF-kB | LIN28/Let-7/STAT3 | Iliopoulos et al. (2009) | |
| Let-7 | TN and HER2 breast cancers Human | Inhibition of CSC maintenance | SHP2 | MAPK/ERK and MYC | RAS/MYC | Aceto et al. (2012) |
| Let-7/miR-200 families | Breast cancer cells (MCF7) Human | Inhibition of EMT | JAK2/STAT3 | LIN28/Let-7 and miR-200/ZEB1 | HMGA2/ZEB1 | Guo et al. (2013) |
| miR-205/-200 family | Human primary breast cancers/ MDCK cells | Maintenance of the epithelial state/tumor suppression | TGF -β | ZEB1–ZEB2 | Gregory et al. (2008) | |
| miR-205 | Breast cancer cells MDA-MB-231 – BT459 – PT Human | Inhibition of EMT and mammary tumorigenesis | JAG1/NOTCH2 | Hes1/ZEB1 | ZEB1/NOTCH2 | Chao et al. (2014) |
| miR-200c | Human primary BCSCs (CD44+/CD24-) | Inhibition of self-renewal | BMI/PRC1 | Shimono et al. (2009) | ||
| miR-200b | Human CD44+/CD24- from MCF10A-SRC | Inhibition of self-renewal/invasion and tumor growth | SUZ12/PRC2 and E-cadherin | Iliopoulos et al. (2010) | ||
| miR-200b/-200c | Multiple human breast cancer cells | Interconversion of CSCs to non-CSCs | TGF -β | ZEB1 | Chaffer et al. (2013) | |
| miR-200c/-141 | Human cancer cells (MDA-MB-231) | Inhibition of EMT/stemness/survival | Jag1/Maml2/3/ZEB1 | Brabletz et al. (2011) | ||
| miR-200c | Human breast cancer cell lines BT549 | Inhibition of EMT/stemness | p53 | ZEB1/BMI-1 | Chang et al. (2011) | |
| miR-22 | Human breast cancer and Mouse models | Promoter of metastasis, EMT, invasiveness and stemness | ZEB1–ZEB2 | TET and miR-200 inhibition | Song et al. (2013) | |
| HOTAIR | Human breast cancer cells (MCF -7; MCF-10A; SK-BR3; MDA-MB-231) | Promoter of tumor metastasis and invasion | Metastasis suppressor genes | PRC2 and chromatin state of several genes | Gupta et al. (2010) | |
| HOTAIR/miR-7 | Breast cancer cell lines (MCF -7; MDA-MB-231) | Promoter/Inhibitor (HOTAIR/miR-7) of EMT/stemness | STAT3 | miR-7:SETDB1 HOTAIR:HoxD10 | Zhang et al. (2014). | |
| Linc-ROR | iPSCs/ES cells | Maintenance of self-renewal | Sox2, Nanog, Oct4 | Self-renewal genes | Sponge for miR-145 family | Wang et al. (2013b) |
| Linc-ROR | Multiple human breast cancer cells | Promoter of EMT/stem-like features | Sponge for miR-205 | Hou et al. (2014) | ||
| Lnc-H19 | Muscle cells and cancer cells | Promoter of muscle differentiation | Differentiation genes/let-7 targets | Sponge for let-7 family | Kallen et al. (2013) | |
| Lnc-H19/miR-675 | Human breast cancer and cell lines (MDA-MB-468) | EMT/promoter of tumor metastasis | TGF -β hypoxia/HGF /SF | PI3K/AKT/Slug | E-cadherin | Matouk et al. (2007) |
| Lnc-ATB | Hepatocellular carcinomas and Human Breast cancer cells (MCF-7) | EMT/promoter of tumor metastasis | TGF-β/IL-11 | ZEB1–ZEB2/STAT3 | Sponge for miR-200 family | Yuan et al. (2014) |
The table summarizes the miRNAs and the lncRNAs, linked to breast cancer stem cells, cited in the text. Shown are: the cell type or tumor type (source) in which the lncRNA has been investigated, the function in that compartment, the upstream and downstream signaling, the target genes and the appropriate references.