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. 2014 Dec 31;15(1):160. doi: 10.1186/s12931-014-0160-8

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© Van de Laar et al.; licensee BioMed Central. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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MST1/MSP is a mitogen for tracheal basal cells and MST1R/RON is expressed in all large airway basal cells in vivo . (A) The MST1R/RON ligand MST1/MSP promotes growth of human tracheal basal cells. Growth was measured by the alamarBlue assay. Each data point represents the mean of triplicate cultures with the standard deviation shown. p values were calculated for the day 13 data point relative to cells growing in control basal medium without EGF and BPE, using a two-tailed student’s t test. (B) Human tracheal tissue stained with anti-MST1R/RON (Santa Cruz). (C) Human nasopharyngeal tissue stained with anti-MST1R/RON. Image is from The Human Protein Atlas online resource (www.proteinatlas.org). Scale bars are 50 μm.