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. 2015 Feb 22;13:13. doi: 10.1186/s12964-015-0092-z

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© Murakami et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Line Graph of IL1B mRNA data from GSE16395. We compared GSE16395 mRNA array data between Langerhans cells (LCs) and LCH cells using the Subio platform. Each line represents a measured value. The red line represents IL1B mRNA expression, which is lower in both LCs and LCH cells according to the intensity of processed signals. However, using raw data signals, IL1B mRNA expression is high in both LCs and LCH cells. This phenomenon indicates that even slight stimuli, such as low temperature or tissue treatment using trypsin for LC isolation from the epidermis, can trigger IL-1β production. As previously reported, IL-1β expression was indicated. In addition IL-1β expression was higher in MS-LCH than SS-LCH.