Table 3.
The association between patients’ pathological data and inflammatory biomarkers
| Variables | Tumor grade a | P * | Tumor stage b | P * | Depth of invasion | P * | Lymph node | P * | Distant metastasis | P * | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| G1-G2 | G3-G4 | I-II | III-IV | T1-T2 | T3-T4 | N0 | N1-N3 | M0 | M1 | ||||||
| NLR | 6.51 ± 10.79 | 5.64 ± 6.81 | 0.512 | 4.73 ± 6.73 | 7.07 ± 10.50 | 0.000 | 4.02 ± 6.67 | 6.54 ± 9.60 | 0.000 | 4.81 ± 8.03 | 6.41 ± 9.45 | 0.000 | 5.00 ± 7.92 | 7.82 ± 10.70 | 0.000 |
| dNLR | 4.08 ± 5.94 | 3.51 ± 3.61 | 0.516 | 3.13 ± 3.63 | 4.31 ± 5.76 | 0.000 | 2.67 ± 3.24 | 4.06 ± 5.29 | 0.000 | 3.01 ± 3.92 | 4.01 ± 5.23 | 0.000 | 3.32 ± 4.51 | 4.61 ± 5.65 | 0.013 |
| PLR | 210 ± 248 | 169 ± 103 | 0.185 | 170 ± 121 | 207 ± 235 | 0.010 | 146 ± 135 | 201 ± 206 | 0.039 | 160 ± 137 | 199 ± 208 | 0.001 | 170 ± 122 | 225 ± 272 | 0.001 |
| LMR | 4.65 ± 3.73 | 4.95 ± 5.83 | 0.808 | 5.74 ± 5.93 | 4.13 ± 3.66 | 0.001 | 6.90 ± 8.55 | 4.36 ± 3.42 | 0.000 | 6.71 ± 8.31 | 4.35 ± 3.40 | 0.000 | 5.70 ± 5.79 | 3.39 ± 1.88 | 0.000 |
NLR, neutrophil count to lymphocyte count; dNLR, neutrophil count to (white cell count – neutrophil count); PLR, platelet count to lymphocyte count; LMR, lymphocyte to monocyte ratio
*Difference between groups was tested by Mann–Whitney U or Kruskal-Wallis test.
aGrade 1 and 2 stand for high or middle differentiated tumor, grade 3 and 4 stand for poorly differentiated tumor.
bTumor stage according to seventh edition of American Joint of Committee on Cancer.