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. 2015 Feb 2;112(7):E796–E805. doi: 10.1073/pnas.1420765112

Fig. 3.

Fig. 3.

Endothelial-dependent influences on myogenic tone and BK channel activity are unaltered in PAs from TgNotch3R169C mice. (A, a–c) Representative traces showing constriction of pressurized (40 mmHg) PAs induced by the SK channel blocker apamin (300 nM), the BK channel blocker paxilline (1 µM), the IK channel blocker charybdotoxin (100 nM), and the eNOS inhibitor L-NAME (100 µM). (B) Summary data expressed as means ± SEM. N.S. indicates not significantly different (P > 0.05; one-way ANOVA). The number of animals is shown in parentheses. (C) Typical recording of the internal diameter of PAs during myogenic constriction in response to increasing intraluminal pressure in the presence of the BK channel blocker paxilline (1 µM). (D) Summary myogenic tone data (means ± SEM) in the presence and absence of paxilline.