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The 4-AP–induced constriction is elevated in PAs from TgNotch3R169C mice. (A, a–c) Representative traces showing constriction of pressurized (40 mmHg) PAs induced by the KV channel blocker 4-AP (1 mM and 5 mM). (B) Summary data expressed as means ± SEM (*P < 0.05; one-way ANOVA). The number of animals is shown in parentheses.
