Fig. 1.

Schematic figure of the human BRCA1 gene. The boxes represent the exons (ex), which are numbered from 1 to 24. The positions of the RNF domain, the coiled-coil domain, and the BRCT repeats are underlined. Proteins interacting with these domains are written underneath the domains. The approximate positions of mutations, carried by the individuals included in the CSR junctional analysis, are indicated by arrows (blue, nonlymphoma patients; red, diffused large B-cell lymphoma patients). All mutations are heterozygous.