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. 2015 Feb 2;112(7):E738–E746. doi: 10.1073/pnas.1417325112

Table 2.

Life course multivariate linear regression using data obtained from multiple imputation: men (n = 3,753)

Model 1 Model 2 Model 3 Model 4
Variables β (SE) P β (SE) P β (SE) P β (SE) P
Mother's education level
 Left school at 15 or later 0 0 0 0
 Left school before 14 0.17 (0.08) 0.03 0.16 (0.08) 0.04 0.07 (0.08) 0.35 0.06 (0.08) 0.44
Father's social class at birth
 Nonmanual 0 0 0 0
 Manual 0.39 (0.08) <0.01 0.37 (0.08) <0.01 0.23 (0.08) <0.01 0.22 (0.08) <0.01
Overcrowding
 >1.5 people per room 0 0 0 0
 ≤1.5 people per room −0.08 (0.10) 0.46 −0.03 (0.10) 0.79 0.02 (0.10) 0.84 0.04 (0.10) 0.70
Mother's BMI
 Normal 0 0 0 0
 Underweight 0.13 (0.17) 0.46 0.10 (0.17) 0.58 0.19 (0.17) 0.26 0.21 (0.17) 0.22
 Overweight 0.29 (0.08) <0.01 0.29 (0.08) <0.01 0.23 (0.08) <0.01 0.22 (0.08) <0.01
 Obese 0.59 (0.16) <0.01 0.55 (0.16) <0.01 0.32 (0.16) 0.05 0.30 (0.16) 0.06
Mother smoked during pregnancy
 No 0 0 0 0
 Sometimes 0.29 (0.14) 0.03 0.26 (0.14) 0.05 0.16 (0.13) 0.22 0.16 (0.13) 0.24
 Moderately 0.12 (0.09) 0.19 0.11 (0.09) 0.25 0.08 (0.09) 0.39 0.08 (0.09) 0.40
 Heavily 0.22 (0.10) 0.03 0.20 (0.10) 0.06 0.09 (0.10) 0.38 0.09 (0.10) 0.39
Birth weight
 Q1: low weight 0 0 0 0
 Q2 −0.27 (0.09) <0.01 −0.25 (0.09) <0.01 −0.24 (0.09) <0.01 −0.22 (0.09) 0.01
 Q3 −0.26 (0.09) <0.01 −0.25 (0.09) <0.01 −0.26 (0.09) <0.01 −0.23 (0.09) 0.01
 Q4: high weight −0.31 (0.09) <0.01 −0.28 (0.09) <0.01 −0.32 (0.09) <0.01 −0.30 (0.09) <0.01
Childhood pathologies
 No 0 0 0
 Yes 0.20 (0.07) <0.01 0.18 (0.07) 0.01 0.15 (0.07) 0.03
ACEs
 None 0 0 0
 One 0.18 (0.08) 0.02 0.06 (0.08) 0.47 0.05 (0.08) 0.54
 Two or more 0.46 (0.13) <0.01 0.25 (0.13) 0.05 0.19 (0.13) 0.14
Smoking status at 23
 Nonsmoker 0 0
 Former smoker −0.17 (0.09) 0.05 −0.16 (0.09) 0.06
 Smoker: less than 10 cigarettes −0.06 (0.15) 0.69 −0.07 (0.15) 0.64
 Smoker: 10–19 cigarettes 0.42 (0.11) <0.01 0.40 (0.11) <0.01
 Smoker: more than 20 cigarettes 0.79 (0.10) <0.01 0.77 (0.10) <0.01
Alcohol consumption at 23
 Moderate 0 0
 Abstainers −0.04 (0.11) 0.73 −0.08 (0.11) 0.43
 Heavy drinkers 0.06 (0.07) 0.39 0.04 (0.07) 0.54
Physical activity at 23
 Physically active 0 0
 Moderately active 0.09 (0.09) 0.32 0.10 (0.09) 0.28
 Inactive 0.16 (0.08) 0.03 0.14 (0.08) 0.08
Malaise inventory at 23
 No 0 0
 Yes 0.06 (0.18) 0.75 0.01 (0.18) 0.95
Education level at 23
 Passed A levels 0 0
 Passed O levels 0.11 (0.09) 0.20 0.09 (0.09) 0.33
 No qualifications 0.26 (0.10) <0.01 0.20 (0.11) 0.07
BMI at 23
 Normal 0 0
 Underweight −0.15 (0.21) 0.46 −0.24 (0.21) 0.24
 Overweight 0.48 (0.09) <0.01 0.47 (0.09) <0.01
 Obese 1.22 (0.24) <0.01 1.16 (0.24) <0.01
Social class at 33
 Nonmanual 0
 Manual −0.03 (0.08) 0.71
Wealth at 33
 Not owner 0
 Owner: Q1 (Low price) −0.17 (0.10) 0.10
 Owner: Q2 −0.15 (0.11) 0.15
 Owner: Q3 −0.39 (0.11) <0.01
 Owner: Q4 −0.43 (0.12) <0.01
Marital status at 33
 Couple 0
 Single 0.22 (0.10) 0.02
 Divorced or widowed 0.15 (0.14) 0.28