Table 1.
Demographic and clinical characteristics according to CHRNA4 rs1044396 polymorphism.
| Overall (n = 483) |
|||
|---|---|---|---|
| CC (n = 162) | CT or TT (n = 321) | p-value | |
| Age (years) | 52 ± 10 | 54 ± 23 | 0.27 |
| Gender, female (%) | 58.9 | 51.4 | 0.09 |
| Self-declared race, White (%) | 59.9 | 64.0 | 0.10 |
| Scholarity, college (%) | 27.2 | 27.4 | 0.55 |
| Body mass index (Kg/m2) | 27 ± 5 | 26 ± 5 | 0.06 |
| FTND | 6.9 ± 2.4 | 6.7 ± 2.5 | 0.66 |
| FTND, ≥6 (%) | 67.9 | 71.1 | 0.39 |
| Issa score, 3 or 4 (%) | 79.3 | 70.4 | 0.38 |
| Hypertension (%) | 42.6 | 40.2 | 0.61 |
| Coronary artery disease (%) | 13.0 | 17.4 | 0.20 |
| Acute myocardial infarction (%) | 16.0 | 19.0 | 0.43 |
| Dyslipidemia (%) | 43.8 | 36.4 | 0.12 |
| Diabetes mellitus type 2 (%) | 17.9 | 17.1 | 0.53 |
| Obesity (%) | 5.6 | 5.6 | 0.98 |
| Depression (%) | 19.1 | 20.6 | 0.71 |
| Anxiety (%) | 20.4 | 18.7 | 0.66 |
| Chronic obstructive pulmonary disease (%) | 11.7 | 16.8 | 0.14 |
| Asthma (%) | 2.5 | 1.9 | 0.66 |
| Number of diagnosed diseases | 2.3 ± 1.6 | 2.5 ± 1.7 | 0.43 |
|
Patients treated with varenicline (n = 167) |
|||
| CC (n = 61) | CT or TT (n = 106) | p-value | |
| Age (years) | 52 ± 9 | 52 ± 11 | 0.84 |
| Gender, female (%) | 57.3 | 55.7 | 0.41 |
| Self-declared race, White (%) | 72.7 | 89.4 | 0.01 |
| Scholarity, college (%) | 32.8 | 34.9 | 0.78 |
| Body mass index (Kg/m2) | 27 ± 4 | 27 ± 5 | 0.46 |
| FTND | 7.2 ± 2.7 | 6.8 ± 2.6 | 0.45 |
| FTND ≥6 (%) | 73.8 | 74.7 | 0.83 |
| Hypertension (%) | 31.1 | 26.4 | 0.51 |
| Coronary artery disease (%) | 8.2 | 10.4 | 0.65 |
| Acute myocardial infarction (%) | 9.8 | 12.3 | 0.63 |
| Dyslipidemia (%) | 23.0 | 26.4 | 0.62 |
| Diabetes mellitus type 2 (%) | 13.0 | 17.9 | 0.10 |
| Obesity (%) | 0.0 | 3.8 | 0.13 |
| Depression (%) | 18.0 | 17.9 | 0.99 |
| Anxiety (%) | 13.1 | 11.3 | 0.73 |
| Chronic obstructive pulmonary disease (%) | 9.8 | 9.4 | 0.93 |
| Asthma (%) | 1.6 | 1.9 | 0.91 |
| Number of diagnosed diseases | 1.9 ± 1.5 | 1.8 ± 1.5 | 0.80 |
FTND, Fagerström test for nicotine dependence (range from 0 to 10 points). Issa score, Issa situational smoking score (range from 0 to 4 points) was made for patients with FTND score ≤4 (n = 84). Issa score was not included for the group of patients with varenicline.