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. 2015 Feb 22;14:50. doi: 10.1186/s12943-015-0309-1

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© Luwor et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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TGF-β Signalling within live individual tumour cells promotes cell motility. A. MDA-MB-231 cells were infected with Ad.CAGA-Td-Tom virus and stimulated with ± TGF-β (5 ng/ml). 24 h later, cells were tracked for 10 h and imaged every 4 min. Images were quantified with the use of Metamorph software, to track the distance moved by individual cells with (i) undetectable Smad3 activity and (ii) Smad3 activity following infection with Ad.CAGA-Td-Tom virus and TGF-β stimulation (n = 10). B. Average Speed (um/min) of each group of 10 cells (*P < 0.05). C. Cells displaying Smad3 activity were divided into 3 categories based on the intensity (low, medium and high) of Smad3 activity. Data represent the average distance travelled over time from each group (n = 7).