Table 1.

Comparison of serum lipids in BN rats after acute and subchronic exposure to FA or O₃.

Age	O3	CHOL mg/dl	HDL CHOL mg/dl	LDL CHOL mg/dl	TRIG mg/dl
Acute
1 month	0 ppm	71.61 ± 4.09††	26.49 ± 1.4††	16.36 ± 0.96††	25.47 ± 1.72†
	0.25 ppm	73.29 ± 4.17	26.41 ± 1.11	16.15 ± 0.59	22.91 ± 1.79
	1 ppm	76.22 ± 2.95	23.89 ± 1.33	16.89 ± 1.98	25.87 ± 3.67
4 months	0 ppm	51.92 ± 1.86	19.64 ± 0.41	11.16 ± 0.57	40.68 ± 5.88
	0.25 ppm	54.46 ± 1.44	19.88 ± 0.65	11.7 ± 0.57	42.78 ± 4.72
	1 ppm	56.05 ± 1.33	18.71 ± 0.75	11.08 ± 0.26	37.37 ± 5.04
12 months	0 ppm	55.89 ± 3.38	18.25 ± 0.36	10.43 ± 0.98	50.74 ± 10.75
	0.25 ppm	59.58 ± 2.26	20.48 ± 0.83	11.56 ± 0.48	47.7 ± 2.16
	1 ppm	58.43 ± 1.5	21.55 ± 0.37**	9.25 ± 0.39	49.27 ± 3.44
24 months	0 ppm	71.58 ± 2.95††	20.25 ± 0.75	11.63 ± 1.00	65.12 ± 4.83††
	0.25 ppm	69.38 ± 1.91	19.33 ± 1.3	10.91 ± 0.57	61.36 ± 3.61
	1 ppm	71.89 ± 1.93	20.93 ± 0.57	10.18 ± 0.68	89.02 ± 12.26
Subchronic
4 months	0 ppm	45.66 ± 1.13	19.17 ± 0.57	10.03 ± 0.55	39.9 ± 3.33
	0.25 ppm	47.33 ± 2.42	20.66 ± 0.62	10.2 ± 0.78	39.09 ± 2.66
	1 ppm	44.71 ± 2.37	19.3 ± 0.61	9.88 ± 0.53	34.56 ± 4.04
12 months	0 ppm	51.16 ± 2.51	19.05 ± 0.56	11.32 ± 0.42	52.73 ± 5.97
	0.25 ppm	50.54 ± 1.73	20.76 ± 0.90	9.59 ± 0.33	40.31 ± 4.91
	1 ppm	57.25 ± 1.13	22.05 ± 0.45**	9.97 ± 0.43	46.98 ± 4.81
24 months	0 ppm	66.65 ± 3.70††	22.94 ± 0.98††	10.71 ± 1.12	95.31 ± 15.33††
	0.25 ppm	61.69 ± 3.25	20.14 ± 1.07*	9.95 ± 0.57	62.82 ± 7.10*
	1 ppm	66.38 ± 3.03	21.91 ± 0.69	10.82 ± 0.25	78.02 ± 2.87

Serum samples were collected during necropsy 18 h after final acute or subchronic exposure and analyzed as described in methods. Values represent non-fasting serum levels.

Abbreviations: total cholesterol (CHOL), high-density lipoprotein cholesterol (HDL CHOL), low-density lipoprotein cholesterol (LDL CHOL), and triglycerides (TRIG).

Each value is the mean ± S.E. of 5–12 rats/group.

Mean values of each serum component are compared for age-factor relative to 4 month old rats († = p < 0.05 †† = p < 0.01).

Significant exposure effects are indicated relative to FA exposed group (* = p < 0.05 ** = p < 0.01).

0 ppm indicates FA exposure.