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. Author manuscript; available in PMC: 2015 Feb 27.
Published in final edited form as: J Neuroimmunol. 2014 Jun 24;274(0):53–61. doi: 10.1016/j.jneuroim.2014.06.009

Fig. 8.

Fig. 8

No differences were found between astro-CCL2-CKO mice as compared to WT littermates during the early phase of EAE. A, Astro-CCL2-CKO mice have similar clinical disease scores as WT mice early during EAE. B, Representative immunofluorescence images and quantitative analysis show that astro-CCL2-CKO and WT have similar levels of Iba-1 (green) globoid macrophage (arrowhead) and CD3 (red) T cell (arrow) infiltrates in the spinal cord dorsal column. Scale bar, 100 µm. Quantitative analyses confirm that astro-CCL2-CKO mice and CCL2 WT mice also have similar levels of diffuse activation of C, reactive astrocytes and D, activated microglial cells in the white and gray matter of the spinal cord early during. E, Quantitative analyses show that astro-CCL2-CKO mice and CCL2 WT mice have similar levels of myelin and axons in the dorsal column of the spinal cord.