Table 2.
Comparison between the studied groups regarding demographic, clinical, and laboratory data.
| Variables | TM (22) | TI (20) | Control (20) | P1 | P2 | P3 |
|---|---|---|---|---|---|---|
| Age (years) | 9.9 ± 5.8 | 11.8 ± 4.6 | 11 ± 6.9 | 0.7 | 0.77 | 0.25 |
| Sex, male, n(%) | 14 (63.6) | 10 (50%) | 8(40) | 0.13 | 0.52 | 0.37 |
| Consanguinity | 12(54.5) | 5 (25) | 3(15) | 0.008 | 0.25 | 0.051 |
| Body weight (Kg ) | 27 ± 12.2 | 34.9 ± 15.9 | 35.1 ±23.1 | 0.66 | 0.71 | 0.80 |
| Height (cm) | 127.9±25.2 | 139.3±20.2 | 132.7±33.8 | 0.43 | 0.65 | 0.12 |
| Chelation, n (%) | ||||||
| • DFO | 12 (54.5) | 7 (35) | ||||
| • Deferazirox | 9 (41) | 12(60) | - | - | - | 0.44 |
| • Combined | 1 (4.5) | 1(5) | ||||
| HCV infection | 11 (50) | 8(40) | - | - | - | 0.52 |
| Splenectomy, n(%) | 9 (41) | 10(50) | - | - | - | 0.55 |
| RBCs TI (ml/kg/year) | 98.7 ± 31.7 | 53.2 ± 23.7 | - | - | - | <0.0001 |
| Hb level (g/dl) | 6.5 ± 0.9 | 7.7 ± 1.2 | 11.7 ± 0.8 | <0.0001 | <0.0001 | 0.001 |
| ALT (IU/L) | 64.1 ± 61.3 | 49 ± 31.3 | 19.2 ± 3.5 | 0.003 | <0.0001 | 0.92 |
| AST (IU/L) | 66.1 ± 53.8 | 52.6 ± 38.9 | 17.6 ± 3.4 | <0.0001 | <0.0001 | 0.37 |
| Serum ferritin(ng/ml) | 3417 ± 2988 | 3210 ± 2500 | 99.5 ± 15.9 | <0.0001 | <0.0001 | 0.8 |
| Serum Hp (mg/dl) | 8.02 ± 0.93 | 8.6 ±0.72 | 122 ± 18.5 | <0.0001 | <0.0001 | 0.034 |
| Serum TfR (μg/ml) | 5.65 ± 0.66 | 4.34 ± 0.71 | 0.88±0.69 | <0.0001 | <0.0001 | <0.0001 |
P1 for comparison between TM and controls.
P2 for comparison between TI and controls.
P3 for comparison between TM and TI.
Bold numerical values indicate significance.