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. 2015 Feb 19;8:451–460. doi: 10.2147/OTT.S71384

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© 2015 Mellai et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

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Sanger direct sequencing.

Notes: Case 1: (A) electropherograms for the stop mutation c.822G>A (p.Trp274*) in PTEN exon 8 in lymphocytes, primary tumor, neurospheres, and adherent cells; (B) electropherograms for the missense mutation c.824G>A (p.Cys275Tyr) in TP53 exon 8 in lymphocytes, primary tumor, neurospheres, and adherent cells. Case 2 (first intervention): (C) electropherograms for the splice variant c.209 + 1G>T in PTEN intron 3 in lymphocytes, primary tumor, and adherent cells.