Table 4.

Lung and bladder cancer ORs in subjects only exposed in utero and as children and in subjects only exposed as adults

Arsenic	Controls	Cases	OR	Unadjusted 95% CI	p-trend	OR	Adjusteda 95% CI	p-trend
LUNG CANCER
Exposed only in utero or as children:b
≤110 μg/L	201	59	1.00	Ref		1.00	Ref
111–800 μg/L	41	20	1.66	(0.90–3.05)		1.88	(0.96–3.71)
>800 μg/L	44	60	4.65	(2.86–7.55)	<0.001	5.24	(3.05–9.00)	<0.001
Exposed only as adults:c
≤110 μg/L	226	74	1.00	Ref		1.00	Ref
111–800 μg/L	41	13	0.97	(0.49–1.91)		0.95	(0.46–1.97)
>800 μg/L	65	28	1.32	(0.79–2.20)	0.34	1.32	(0.75–2.34)	0.35
BLADDER CANCER
Exposed only in utero or as children:b
≤110 μg/L	201	29	1.00	Ref		1.00	Ref
111–800 μg/L	41	13	2.19	(1.05–4.58)		2.94	(1.29–6.70)
>800 μg/L	44	48	7.56	(4.30–13.30)	<0.001	8.11	(4.31–15.25)	<0.001
Exposed only as adults:c
≤110 μg/L	226	30	1.00	Ref		1.00	Ref
111–800 μg/L	41	12	2.20	(1.04–4.66)		2.21	(1.03–4.74)
>800 μg/L	65	42	4.87	(2.83–8.38)	<0.001	4.71	(2.61–8.48)	<0.001

Abbreviations: CI, confidence interval; OR, odds ratio; Ref, reference

^aAdjusted for age, sex, and smoking.

^bAverage arsenic water concentrations in the three exposure categories were 49.6, 254.6, and 860 μg/L.

^cAverage arsenic water concentrations in the three exposure categories were 45.8, 313.2, and 860 μg/L.