Table 1. Model variables.

Nomenclature	Description	Units
Γi=G1,G2	cyclin transition functions	n/a
ΓE,i	cyclin E1 transition function on sub-interval i	n/a
ΓB,k	cyclin B1 transition function on sub-interval k	n/a
ΓS	DNA transition function	n/a
μ	cell growth rate	h-1
cycE	cyclin E1 distributed content	% cyclin
cycEmax	maximum cyclin E1 content used for domain truncation	% cyclin
cycB	cyclin B1 distributed content	% cyclin
cycBmax	maximum cyclin B1 content used for domain truncation	% cyclin
cycBmin	minimum cyclin B1 content used for the domain start	% cyclin
DNA	DNA distributed content	DNA relative content
fi = G1,S,G2M	cell fraction in phase i	n/a
flim	Monod kinetics functions	n/a
Glc	extracellular glucose concentration	mM
Glu	extracellular glutamate concentration	mM
hi = E,DNA,B	resolution of a sub-interval (bin)	% cyclin or DNA relative content
Lac	extracellular lactate concentration	mM
mAb	antibody concentration	mg/L
Ni = G1,S,G2	number of cells distributed on a variable for each phase	Cells
NE,i	number of cells on sub-interval i of domain cyclin E1	Cells
NDNA,j	number of cells on sub-interval j of domain DNA	Cells
NB,k	number of cells on sub-interval k of domain cyclin B1	Cells
ni = E,DNA,B	number of sub-intervals (or bins) within each domain interval	n/a
Qi = Glu,Glc	substrate consumption rate	mM/cells/h
ri	growth functions of the distributed variable	h-1
rE,i	cyclin E1 growth function on sub-interval i	% cyc E/h
rDNA,j	DNA growth function on sub-interval j	DNA/h
rB,k	cyclin B1 growth function on sub-interval k	% cyc B/h
total	total number of viable cells	cells
phasei = G1,S,G2	number of cells in phase i	cells
(s)	substrate/metabolite concentration	mM
V	Volume	mL
XV	viable cell density	cells/mL
XD	death cell density	cells/mL