Table 3. MC values of several β-lactams and β-lactamase content for the extended-spectrum b-lactamase –producing Enterobacteriaceae in blood cultures*.
| Hospitalization unit a | Species | MICs (μg/mL)† |
β-Lactamase content c |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| CAZ | CTX | FEP | CAZ/TZB | CTX/TZB | FEP/TZB | SHV | TEM | CTX-M | |||
| Emergency | Escherichia coli | 2† | 8 | 2 | 0.19 | 0.032 | 0.023 | – | – | CTX-M-1 | |
| Rhumatology | E. coli | 1 | 12 | 2 | 0.19 | 0.032 | 0.016 | – | TEM-1 | CTX-M-1 | |
| Emergency | E. coli | 32 | 48 | 8 | 0.75 | 0.25 | 0.064 | SHV-12‡ | – | CTX-M-3 | |
| Emergency | E. coli | 1.5 | 16 | 6 | 0.38 | 0.094 | 0.064 | – | TEM-1 | CTX-M-14 | |
| ICU | E. coli | 1 | 16 | 3 | 0.19 | 0.016 | 0.023 | – | TEM-1 | CTX-M-14 | |
| Nephrology | E. coli | 0.5 | 12 | 1.5 | 0.094 | 0.047 | 0.016 | – | TEM-1 | CTX-M-14 | |
| Nephrology | E. coli | 0.38 | 8 | 1.5 | 0.125 | 0.032 | 0.023 | – | TEM-1 | CTX-M-14 | |
| Surgery | E. coli | 0.5 | 12 | 2 | 0.19 | 0.032 | 0.032 | – | TEM-1 | CTX-M-14 | |
| ICU | E. coli | 8 | 96 | 6 | 0.19 | 0.032 | 0.032 | – | – | CTX-M-15 | |
| ICU | E. coli | 1 | 16 | 0.75 | 0.094 | 0.032 | 0.047 | – | – | CTX-M-15 | |
| Infectious diseases | E. coli | 12 | 128 | 12 | 0.25 | 0.094 | 0.064 | – | – | CTX-M-15 | |
| Infectious diseases | E. coli | 16 | 128 | 12 | 0.19 | 0.094 | 0.094 | – | – | CTX-M-15 | |
| Surgery | E. coli | 12 | 128 | 12 | 0.38 | 0.5 | 2 | – | – | CTX-M-15 | |
| Urology | E. coli | 16 | 192 | 16 | 0.25 | 0.19 | 0.064 | – | TEM-1 | CTX-M-15 | |
| Urology | E. coli | 12 | 192 | 8 | 0.25 | 0.125 | 0.064 | – | TEM-1 | CTX-M-15 | |
| Infectious diseases | E. coli | 32 | 128 | 16 | 0.19 | 0.047 | 0.064 | – | TEM-1 | CTX-M-15 | |
| Nephrology | E. coli | 48 | 6 | 1 | 0.38 | 0.19 | 0.094 | SHV-12 | TEM-1 | – | |
| Nephrology | E. coli | 48 | 6 | 1 | 0.38 | 0.19 | 0.094 | SHV-12 | TEM-1 | – | |
| Infectious diseases | E. coli | 12 | 128 | 8 | 0.19 | 0.047 | 0.023 | – | – | CTX-M-15 | |
| Nephrology | E. coli | 16 | 128 | 12 | 0.25 | 0.094 | 0.047 | – | – | CTX-M-15 | |
| ICU | E. coli | 256 | 256 | 192 | 32 | 24 | 2 | – | – | CTX-M-15 | |
| ICU | E. coli | 8 | 96 | 6 | 0.19 | 0.064 | 0.064 | – | – | CTX-M-15 | |
| ICU | E. coli | 12 | 128 | 6 | 0.125 | 0.064 | 0.125 | – | – | CTX-M-15 | |
| Infectious diseases | E. coli | 32 | 256 | 24 | 0.5 | 0.19 | 0.094 | – | – | CTX-M-15 | |
| Infectious diseases | E. coli | 32 | 256 | 24 | 0.5 | 0.19 | 0.094 | – | – | CTX-M-15 | |
| Infectious diseases | E. coli | 256 | 256 | 16 | 0.5 | 0.016 | 0.094 | – | – | CTX-M-15 | |
| Pneumology | E. coli | 32 | 256 | 16 | 0.5 | 0.094 | 0.032 | – | TEM-1 | CTX-M-15 | |
| Emergency | E. coli | 256 | 12 | 1 | 0.094 | 0.032 | 0.016 | – | – | CTX-M-27 | |
| ICU | E. coli | 1 | 12 | 1 | 0.094 | 0.023 | 0.023 | – | – | CTX-M-27 | |
| Nephrology |
E. coli
|
2
|
2 |
1.5
|
0.094 |
0.016 |
0.016 |
|
– |
TEM-1 |
CTX-M-55
|
| ICU | Klebsiella pneumoniae | 3 | 32 | 4 | 0.125 | 0.023 | 0.032 | – | TEM-1 | CTX-M-15 | |
| Infectious diseases | K. pneumoniae | 32 | 256 | 8 | 0.38 | 0.125 | 0.094 | – | TEM-1 | CTX-M-15 | |
| ICU | K. pneumoniae | 128 | 256 | 64 | 1 | 0.25 | 0.19 | LEN-5 | – | CTX-M-15 | |
| ICU | K. pneumoniae | 256 | 256 | 32 | 2 | 0.5 | 2 | LEN-5 | TEM-1 | CTX-M-15 | |
| Nephrology | K. pneumoniae | 16 | 128 | 6 | 0.25 | 0.064 | 0.047 | SHV-1 | TEM-1 | CTX-M-15 | |
| Hepatology | K. pneumoniae | 6 | 96 | 6 | 0.19 | 0.047 | 0.19 | SHV-1 | TEM-1 | CTX-M-15 | |
| Nephrology | K. pneumoniae | 8 | 96 | 4 | 0.25 | 0.064 | 0.032 | SHV-1 | TEM-1 | CTX-M-15 | |
| ICU | K. pneumoniae | 48 | 256 | 24 | 0.5 | 0.064 | 0.064 | SHV-1 | TEM-1 | CTX-M-15 | |
| Hepatology | K. pneumoniae | 16 | 64 | 6 | 0.5 | 0.25 | 0.125 | SHV-11 | TEM-1 | CTX-M-15 | |
| Hepatology | K. pneumoniae | 12 | 48 | 6 | 0.5 | 0.19 | 0.094 | SHV-11 | TEM-1 | CTX-M-15 | |
| ICU | K. pneumoniae | 12 | 128 | 12 | 0.38 | 0.047 | 0.094 | SHV-11 | TEM-1 | CTX-M-15 | |
| Nephrology | K. pneumoniae | 48 | 256 | 16 | 0.5 | 0.19 | 0.5 | SHV-11 | TEM-1 | CTX-M-15 | |
| ICU |
K. pneumoniae
|
256 |
256 |
24 |
0.25 |
0.047 |
0.064 |
|
SHV-28 |
TEM-1 |
CTX-M-15
|
| ICU | Enterobacter cloacae | 96 | 256 | 32 | 1 | 1 | 0.25 | – | – | CTX-M-15 | |
| Nephrology | E. cloacae | 12 | 192 | 12 | 0.25 | 0.125 | 0.047 | – | TEM-1 | CTX-M-15 | |
| ICU |
E. cloacae
|
12 |
128 |
6 |
0.25 |
0.047 |
0.047 |
|
SHV-1 |
TEM-1 |
CTX-M-15
|
| Emergency | Citrobacter freundii | 16 | 12 | 2 | 2 | 1 | 0.5 | – | TEM-3 +TEM-1 | CTX-M-55 | |
ICU, intensive care unit, CAZ, ceftazidime; CTX, cefotaxime; FEP, cefepime; TZB, tazobactam; –, negative PCR result. †Numbers in bold text indicate MIC values reported in the range of susceptibility according to Clinical Laboratory Standards Institute guidelines as updated in 2014 (susceptible means MIC ≤1 μg/mL, ≤4 μg/mL and ≤2 μg/mL for cefotaxime, ceftazidime and cefepime, respectively). ‡Bold, underlined text indicates ESBL names.