Fig 7. Conserved complex components are enriched for essential proteins.

This correlation is even more pronounced in Mycoplasma (blue). Protein complexes of E. coli [5] are compared to complexes of M. pneumoniae [6] and vice versa. Fraction of conservation and fraction of essentiality are calculated as described in Materials and Methods. Each node represents a single protein complex with relative size corresponding to the size of the complex in number of components. Kühner complex 50 and its corresponding Hu complex 77 are indicated as an example complex match.