Skip to main content
. 2015 Feb 27;10(2):e0117685. doi: 10.1371/journal.pone.0117685

Fig 8. Additional metabolite time course data compared to benzoylecgonine (BE).

Fig 8

Experimental conditions for each group of cells are shown above the graph with solid black lines indicating exposure to cocaine media. Anhydroecgonine (AHE) and hydroxybenzoylecgonine (HOBE), two additional metabolites of cocaine, provide examples of both variation between naïve and experienced cell groups in the case of AHE and consistency between these two groups in the case of HOBE. The increases in BE and AHE from naïve to experienced groups are statistically significant with respective p values of 5.7 x 10 –4 and 1.12 x 10 –3. Three unidentified metabolites (m/z 645, m/z 478, and m/z 330) that contribute to the separation between media exposure groups are also shown. m/z 330 and m/z 478 show no statistical significance between naïve and experienced cell groups while the increase in m/z 645 is statistically significant (p = 1.6 x 10 –3 ).