FIGURE 3.
Increased inflammation in the lungs of Sftpc−/− mice after infection with P. aeruginosa. Lungs of 2-wk-old Sftpc+/+ and Sftpc−/− mice were assessed before (A and B), and 24 h after (C and D) administration of P. aeruginosa. Areas of subtle interstitial thickening and inflammatory cells were infrequently seen in Sftpc−/− lungs before challenge (B). Extensive granulocytic infiltrates were observed in the lungs of infected Sftpc−/− mice (D) compared with infected control mice (C). Arrows indicate bronchiolar epithelium. Final magnification is shown at ×77.