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. Author manuscript; available in PMC: 2015 Feb 27.
Published in final edited form as: Nat Med. 2014 Jun 15;20(7):759–763. doi: 10.1038/nm.3579

Fig. 4.

Fig. 4

Matching plasma corticosterone in high fat fed-corticosterone infused rats to that of T1D animals drives excess lipolysis, gluconeogenesis, and hyperglycemia. (a) Fasting plasma glucose. (b) Hepatic gluconeogenesis from pyruvate (solid bars) and glycerol (dashed bars). Gluconeogenesis from glycerol was increased (P<0.01) in corticosterone-infused rats. (c) Fasting plasma insulin. (d) TCA cycle flux from fatty acid oxidation (solid bars) and through PDH (dashed bars). (e)–(g) Whole-body glycerol, fatty acid (palmitate) and acetate turnover. (h) Liver acetyl CoA concentration. In all panels, data are mean ± S.E.M., n=6 per group. *P<0.05, **P<0.01, ****P<0.0001.