Table 3. Diminished increase of ABAp after oral glucose load in GDM and reversal to normal after childbirth.
| NGT | GDM | ||||||
|---|---|---|---|---|---|---|---|
| N | 7 | 9 | p | ||||
| BMI (kg/m2) | 24.9±3.1 | 25.5±4.9 | 0.767 | ||||
| Age (years) | 37.0±3.7 | 37.1±1.4 | 0.934 | ||||
| prepartum | postpartum | prepartum | postpartum | p | |||
| FPG (mg/dL) | 72.4±7.2 | p = 0.117 | 67.9±9.3 | 80.7±5.8 | p = 0.007 | 70.3±11.1 | 0.015 * 0.631# |
| Fasting ABAp (nM) | 1.15±0.69 | p = 0.011 | 2.33±1.49 | 0.54±0.62 | p = 0.0002 | 2.39±0.98 | 0.043 * 0.708# |
| ABA AUC (nmol/L*min) | 191.2±78.3 | p = 0.113 | 298.3±105.2 | 79.4±56.9 | p = 0.011 | 376.5±98.9 | 0.033 * 0.113# |
| Glucose AUC (mg/dL*min) | 12604±256 | p = 0.686 | 12116±2182 | 15546±2066 | p = 0.022 | 12258±3084 | 0.015 * 0.914# |
| Insulin AUC (mU/L*min) | 5984±2942 | p = 0.284 | 4911±1889 | 7465±3406 | p = 0.015 | 5438±3641 | 0.237* 0.894# |
Plasma ABA, glucose and insulin concentrations were measured at 0, 60 and 120 min during a standard gestational diabetes screen at the 24th-28th week (prepartum). The same test was repeated 8–12 weeks after childbirth (postpartum). ABAp was measured by ELISA.
*unpaired t test NGT prepartum vs GDM prepartum
#unpaired t test NGT postpartum vs GDM postpartum.