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. 2015 Feb 27;10(2):e0119723. doi: 10.1371/journal.pone.0119723

Fig 7. Cetuximab inhibit tumor-induction angiogenesis by down-regulating NOTCH1, HIF-1α pathway in Tgfbr1/Pten 2cKO mice HNSCC.

Fig 7

(A) immunohistochemical analyses of EGFR, Hes1, HIF-1α and frozen section immunohistochemical analysis of CD31 in both cetuximab and vehicle-treated Tgfbr1/Pten 2cKO mice HNSCC tissues. (B) Quantitative of histoscore of EGFR, HIF-1α, HES1, CD31 expression in vehicle group and cetuximab-treated group from Tgfbr1/Pten 2cKO mice HNSCC tissues. Mean ± SEM, ***, P < 0.001; student t analysis; Scale bars, 100μm. (C) The expression levels of EGFR, p-EGFRTyr1068, HIF-1α, HES1 and VEGFA protein were analyzed by western blots in both cetuximab and vehicle-treated Tgfbr1/Pten 2cKO mice HNSCC tissues.