Table 5. Spearman correlations between baseline and percent change in Lp(a) and lipid and lipoprotein variables in the mipomersen treated patients.

Baseline		ApoB	Total Cholesterol	LDL-C	Corrected LDL-C	HDL-C	Triglycerides
Lp(a)	Spearman correlation coefficient	0.29	0.11	0.10	-0.15	-0.02	-0.06
	p-value	<.0001	0.093	0.093	0.014	0.74	0.34
ApoB	Spearman correlation coefficient		0.93	0.94	0.82	-0.21	0.15
	p-value		<.0001	<.0001	<.0001	0.0006	0.014
Total Cholesterol	Spearman correlation coefficient			0.96	0.91	-0.04	0.10
	p-value			<.0001	<.0001	0.50	0.094
LDL-C	Spearman correlation coefficient				0.94	-0.17	-0.02
	p-value				<.0001	0.01	0.77
Corrected LDL-C	Spearman correlation coefficient					-0.20	0.01
	p-value					0.001	0.89
HDL-C	Spearman correlation coefficient						-0.15
	p-value						0.017
Lp(a)	Spearman correlation coefficient	0.43	0.37	0.36	0.30	0.08	0.16
	p-value	<.0001	<.0001	<.0001	<.0001	0.20	0.01
ApoB	Spearman correlation coefficient		0.94	0.95	0.92	0.03	0.57
	p-value		<.0001	<.0001	<.0001	0.58	<.0001
Total Cholesterol	Spearman correlation coefficient			0.96	0.95	0.16	0.54
	p-value			<.0001	<.0001	0.011	<.0001
LDL-C	Spearman correlation coefficient				0.98	0.09	0.46
	p-value				<.0001	0.17	<.0001
Corrected LDL-C	Spearman correlation coefficient					0.09	0.44
	p-value					0.13	<.0001
HDL-C	Spearman correlation coefficient						-0.14
	p-value						0.027

LDL-C was corrected for Lp(a) cholesterol content by subtracting 0.3*Lp(a) mass from measured LDL-C [LDL-C corr = LDL-C - 0.3*Lp(a)].