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Stability of oligonucleotides in bovine serum. Oligonucleotides (RNA, DNA, LNA5 and anti-loop LNA5) derived from the aptamer R0616 were incubated in bovine serum at 37°C. Aliquots were taken at the time point indicated and analysed on a 20% denaturing 7 M urea/polyacrylamide gel. Bands corresponding to the oligonucleotides were revealed by the Stains All procedure.
