Fig. 1.

Host conditioning with anti-CD40 induces high-level T cell accumulation in the lymphoid organs and brains of SV11 mice at early time points. Groups of mice received either anti-CD40, WBI, or no conditioning regimen with TCR-IV T-cell ACT. Representative plots show MHC tetramer staining (mean ± SEM) of TCR-IV T cells on days +4 and +5 in a spleen and c brain. Quantification of TCR-IV T-cell accumulation (mean ± SEM) in b spleen and d brain of mice that received ACT with the indicated treatments. n = 3 mice/group (except n = 2 for day +4 control group). Data shown are from one experiment and representative of two independent experiments. Asterisks above connecting lines indicate significant differences between time points. Asterisks next to vertical brackets indicate significant differences between treatment groups. *p < 0.05; **p < 0.01; ns not significant