Fig. 3.

Donor T cells contract dramatically in anti-CD40-conditioned SV11 mice. Groups of SV11 mice were treated as in Fig. 2 and euthanized on days +6 and +10 post-ACT. Accumulation of tetramer-IV⁺ T cells is shown as percentage of CD8⁺ fraction in a spleen and b brain and as total number of TCR-IV T cells in c spleen and d brain. Using sample means in parts c and d, the magnitude of TCR-IV T-cell contraction from day +6 to +10 was graphed for e spleen and f brain. Data are pooled from two experiments with a total of 3–6 mice/group. *p < 0.05; ***p < 0.001; ****p < 0.0001