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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2015 Jan 22;35(3):573–579. doi: 10.1161/ATVBAHA.114.304393

FIGURE 6. Model for integrated TGFβ-Wnt16-Notch signaling network in VSMC transformation.

FIGURE 6

A, In wild-type (Mgp+/+) aortic tissue, MGP represses TGFβ production in VSMCs, Wnt16 is abundant, and Notch signaling is active supporting a stable, contractile phenotype of VSMCs. B, In the aortae of MGP-null (Mgp−/−) mice, TGFβ production is elevated leading to down-regulation of Wnt16 and repression of Notch signaling, and allowing for chondrogenic transformation of VSMCs by additional TGFβ-mediated events.