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. 2015 Jan 20;43(4):2433–2441. doi: 10.1093/nar/gkv029

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© The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Two-state model of CUG-expansions in foci or diffuse states. DDX5 and DDX6 exert opposite effects on CUG-foci potentially by promoting (DDX5) or restricting (DDX6) MBNL1 binding to CUG-repeats allowing for dynamic changes between a focal/insoluble state and a diffuse/soluble state (see text for further details).