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Double rolling circle mechanism as occurring in viroid-like satellite RNAs (50). Here, self-cleavage of the multimeric (−)-strand is mediated by a hammerhead ribozyme, whereas self-cleavage of the multimeric (+)-strand occurs by hairpin ribozyme action. A similar mechanism is employed in the hepatitis-δ-virus replication, as well as in other satellite RNAs and viroids.
