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. 2015 Jan 27;43(4):2466–2485. doi: 10.1093/nar/gkv047

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© The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Glycine, serine and aspartate pathways. Synthesis of glycine and N⁵,N¹⁰-methylene tetrahydrofolate (N⁵,N¹⁰-CH₂-THF) from glucose via the One-Carbon pathway. N⁵,N¹⁰-CH₂-THF is further converted to N¹⁰-formyl-THF for incorporation into purine rings. Enzymes: 1: Hexokinase (HK); 2: 3-phosphoglycerate dehydrogenase (PHGDH); 3: phosphoserine aminotransferase (PSAT); 4: phosphoserine phosphatase (PSPH); 5: Serine Hydroxymethyltransferase (SHMT).