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. 2015 Feb 10;43(4):2400–2411. doi: 10.1093/nar/gkv072

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© The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 3. — A distinct RNA recognition mode in the Hfq-A_us and Hfq-A_ds complex structures compared with the Hfq-A₇ structure. Hfq is shown as a gray surface. (A) A_us and A_ds bind to Hfq in a similar conformation. A_us and A_ds are shown as orange and magenta sticks, respectively. A new nucleotide binding pocket close to the central pore of Hfq (formed near the interface of two adjacent Hfq subunits) is circled with a dotted line. (B) A_us and (C) A_ds binding at the distal side of Hfq differs from that of A₇ (blue sticks). Nucleotide U71 of A_ds binds to the adenosine selective site (‘A-site’) in the ‘A-R-N’ motif and is highlighted with a dotted circle in panel (C).