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. 2015 Feb 4;43(4):1997–2007. doi: 10.1093/nar/gkv074

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© The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 4. — Estimation of multi-factor mediated dysregulations affected by the module. (A) The cancer associated biological processes (top) and pathways (bottom) enriched by the dysregulated genes of 17 member genes. (B) The transcription factors account for most of dysfunctions of dysregulated genes. (C) Nine member genes affect ‘epidermal growth factor receptor signaling pathway’ through distinct dysregulation of their dysregulated genes. The dysregulation of dysregulated genes is arranged in order: copy number, methylation, miRNA, TF. The genes mentioned in the text are labeled by arrows. (D) The literature-curated dysregulated relationships linked with EGFR.