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. 2015 Feb 4;43(4):1997–2007. doi: 10.1093/nar/gkv074

Figure 5.

Figure 5.

The disturbance of Glioma pathway affected by two gene sets in the core module contributing to GBM survival. (A) Two gene sets (I and II) in the core module characterized two subgroups using unsupervised hierarchical clustering of GBM patients with genomic alterations in the module. The ‘subtype’ bar represents four subtypes (including classical, proneural, mesenchymal and neural) identified using expression of genes determined in a previous study. (B) The gene set I including EGFR, PTEN, PDGFRA, CDKN2A, MDM4, KIT, PIK3C2B, RB1 and PHKG1 directly participates in Glioma pathway. (C) The gene set II including CDK4, METTL1, OS9, AVIL, CTDSP2, KIF5A, DCTN2 and DDIT3 indirectly regulates the Glioma pathway through dysregulated genes. The digits within the four rectangles represent the frequency of copy number, methylation, miRNA and TF-mediated dysregulations of dysregulated genes. The different regulatory factors are affiliated to the dysregulated genes. (D) Both of the two gene sets (I and II) contribute to the GBM survival.