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. 2015 Feb 8;43(4):2164–2176. doi: 10.1093/nar/gkv092

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© The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — Models for Cdc13-telomere interaction. (A) The proposed models for the CtCdc13AA–DNA and CpCdc13AB–DNA complexes are schematically illustrated. (B) Left: The phylogenetic relationship among the Candida species is displayed. Right: The telomere repeat units in these organisms are shown along with the proposed Cdc13A and Cdc13B target sites. The region bound by Cdc13B is shaded in orange, and the nucleotides in C. tropicalis, C. orthopsilosis and C. metapsilosis G-strand that cause reduced binding by CpCdc13AB are shown in blue and underlined.