Table 1.
Effects of treatments on blood biochemistry and hepatic parameters in MCS-diet-or MCD-diet-fed mice receiving four-weeks of treatment.
| Parameter | MCS Diet | MCD Diet | ||||
|---|---|---|---|---|---|---|
| Vehicle | Vehicle | 6-Gingerol (mg/kg/day) | Ciprofibrate | |||
| 25 | 50 | 100 | (10 mg/kg/day) | |||
| Initial body weight (BW) (g) | 21.13 ± 1.54 | 21.09 ± 1.28 | 21.17 ± 1.49 | 21.03 ± 1.37 | 21.14 ± 1.62 | 21.20 ± 1.81 |
| Final BW (g) | 28.47 ± 1.83 | 14.87 ± 1.42 | 15.17 ± 1.68 | 15.47 ± 1.53 | 15.21 ± 1.73 | 15.39 ± 1.84 |
| Liver absolute weight (g) | 1.41 ± 0.12 | 0.49 ± 0.06 | 0.52 ± 0.08 | 0.56 ± 0.06 | 0.58 ± 0.04 | 0.59 ± 0.06 |
| Liver relative weight (%) | 4.91 ± 0.27 c | 3.30 ± 0.31 a | 3.42 ± 0.26 a | 3.62 ± 0.22 a | 3.85 ± 0.25 a | 3.90 ± 0.29 a |
| Plasma glucose (mg/dL) | 95.12 ± 2.64 c | 81.17 ± 4.17 a | 82.24 ± 3.83 a | 84.45 ± 3.26 a | 83.33 ± 3.94 a | 81.26 ± 4.03 a |
| Plasma TC (mg/dL) | 153.90 ± 3.96 d | 25.39 ± 4.28 b | 24.36 ± 4.63 b | 24.26 ± 4.48 b | 25.65 ± 4.12 b | 26.52 ± 3.91 b |
| Plasma TG (mg/dL) | 98.81 ± 3.02 d | 52.36 ± 3.11 b | 57.52 ± 3.73 b | 53.91 ± 3.96 b | 52.49 ± 4.02 b | 56.30 ± 3.24 b |
| Plasma ALT (U/L) | 50.61 ± 6.27 d | 297.14 ± 16.23 b | 248.41 ± 15.78 b,c | 180.44 ± 14.56 b,c | 124.45 ± 12.47 a,d | 94.23 ± 10.87 a,d |
| Plasma AST (U/L) | 115.21 ± 10.91 d | 464.85 ± 17.79 b | 386.03 ± 16.55 b,c | 280.11 ± 17.35 b,c | 207.29 ± 18.40 a,d | 166.25 ± 13.24 a,d |
| Hepatic TC (µmol/g liver) | 12.23 ± 0.62 d | 20.64 ± 1.16 b | 18.82 ± 1.27 b,c | 17.04 ± 1.04 b,c | 15.22 ± 1.17 a,c | 14.56 ± 1.46 a,d |
| Hepatic TG (µmol/g liver) | 9.16 ± 0.82 d | 18.61 ± 1.28 b | 15.52 ± 1.17 b | 13.18 ± 1.51 b,c | 11.77 ± 1.09 a,c | 11.06 ± 1.21 d |
The vehicle (distilled water) used to prepare the tested medication solution was given at the same volume. Values (mean ± SD) were obtained from each group of eight animals in each group after four weeks of the experimental period. a p < 0.05 and b p < 0.01 compared to the values of vehicle-treated MCS-diet fed mice in each group, respectively. c p < 0.05 and d p < 0.01 compared to the values of vehicle-treated MCD-diet fed mice in each group, respectively.