Table 1.
IC50 values of selected bromophenol derivatives against five human cancer cell lines.
| Compd | IC50 (μg/mL) a | ||||
|---|---|---|---|---|---|
| A549 | Bel7402 | HepG2 | Hct116 | Hela | |
| 4g | 6.6 ± 0.82 | 9.2 ± 0.84 | 13.2 ± 2.42 | 9.1 ± 0.13 | 7.4 ± 0.22 |
| 4h | 14.4 ± 1.86 | 12.3 ± 0.23 | 14.3 ± 0.86 | 9.8 ± 0.55 | 8.3 ± 0.67 |
| 4i | 9.9 ± 0.11 | 22.3 ± 1.11 | NA b | NA | NA |
| 5h | 10.1 ± 0.72 | 9.7 ± 2.35 | 11.2 ± 1.26 | 8.6 ± 0.26 | 18.0 ± 0.13 |
| 6d | 25.4 ± 0.82 | 18.6 ± 0.91 | NA | 5.6 ± 0.42 | 17.6 ± 0.89 |
| 6e | NA | NA | NA | 9.8 ± 0.20 | NA |
| 7a | 12.5 ± 0.19 | 7.9 ± 0.26 | 25.0 ± 0.18 | 6.1 ± 0.23 | 8.6 ± 0.14 |
| 7b | 12.5 ± 0.45 | 12.5 ± 0.39 | 14.2 ± 0.77 | 8.2 ± 0.54 | 9.3 ± 0.47 |
| TTEDM c | NA | 44.1 ± 1.19 | NA | 32.3 ± 2.03 | 23.5 ± 1.41 |
| Sunitinib d | 10.4± 0.54 | 3.2 ± 0.15 | 4.5 ± 0.23 | 2.8 ± 0.27 | 1.6 ± 0.08 |
a IC50: Concentration of the compound producing 50% cell growth inhibition after 48 h of drug exposure, as determined by the MTT assay. Each experiment was run at least three times, and the results are presented as average values ± standard deviation; b NA: Compound showing IC50 value > 50 μg/mL; c 2,2',3-tribromo-3',4,4',5-tetrahydroxy-6'-ethyloxymethyldiphenylmethane (TTEDM) is a marine bromophenol compound derived from marine algae. P.; d Sunitinib as the positive control.