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Cytotoxic activity of pachastrissamine (1) and its carbocyclic analogues, 4a–c.
| Compound | IC50 (μM) a | ||||
|---|---|---|---|---|---|
| HCT-116 b | SNU-638 c | MDA-MB-231 d | PC-3 e | Caki-1 f | |
| 1 | 1.0 | 1.2 | 0.7 | 0.7 | 1.7 |
| 4a | 9.7 | 12.8 | 6.1 | 7.6 | 12.1 |
| 4b | 1.0 | 1.7 | 1.8 | 1.0 | 3.2 |
| 4c | 3.2 | 4.4 | 4.1 | 3.1 | 6.6 |
a 50% inhibition concentration; b HCT-116, human colon cancer cell line; c SNU-638, human stomach cancer cell line; d MDA-MB-231, human breast cancer cell line; e PC-3, human prostate cancer cell line; f Caki-1, human renal cancer cell line.
