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Inhibitory activity of pachastrissamine (1) and its carbocyclic analogues, 4a–c, against sphingosine kinases.
| Compound | IC50 (μM) a | |
|---|---|---|
| SphK1 | SphK2 | |
| 1 | 12.0 | 41.8 |
| 4a | 58.2 | >100 |
| 4b | 7.5 | 20.1 |
| 4c | 41.3 | >100 |
| DMS b | 6.6 | 19.9 |
a 50% inhibition concentration; b N,N-dimethylsphingosine.
