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. 2015 Jan 23;7(2):219–237. doi: 10.3390/toxins7020219

Figure 4.

Figure 4

Figure 4

Dose-dependent antiproliferative effects of the analogues, AaeAP1a and AaeAP2a, on the human cancer cell lines, H460, MB435s, MCF-7 and PC3, after 24 h of incubation. The levels of significance are: * p < 0.05; ** p < 0.01; *** p < 0.001. Note that at low concentrations (10−9 M and 10−8 M), AaeAP1a significantly increased the proliferation of H460 cancer cells (p < 0.01). AaeAP2a significantly increased (p < 0.05) the proliferation of MB435s cancer cells at 10−9 M and the proliferation of MCF-7 cancer cells at 10−8 M (p < 0.05) and at 10−9 M (p < 0.01). The growth inhibition of cells at each peptide concentration was calculated as a percentage of the growth observed in controls, which was treated as 100%.