Table 1.
Effects of C3 uptake of the tested compounds. (−, no effect on the RhoA shift; +, RhoA shift is delayed/faster or missing compared to the control).
| Compound | Mechanism | HT22 | J774A.1 |
|---|---|---|---|
| Bafilomycin A1 | blocks endosomal acidification | − | − |
| Brefeldin A | blocks protein trafficking | − | − |
| Methyl-β-cyclodextrin (MBCD) | blocks caveolin-dependent endocytosis | − | − |
| Filipin | blocks caveolin-dependent endocytosis | − | − |
| Nystatin | blocks caveolin-dependent endocytosis | − | − |
| Chlorpromazine | blocks clathrin-dependent endocytosis | − | − |
| Latrunculin B | blocks actin polymerization | − | − |
| Nocodazole | blocks polymerization of microtubules | − | − |
| Acrylamide | interrupts vimentin filament network | + | + |
| Dynasore | blocks dynamin-dependent endocytosis | + | + |