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. 2015 Feb 22;13:71. doi: 10.1186/s12967-015-0393-4

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© Machida et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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ROC analysis. Receiver operating curve (ROC) analysis for the evaluation of diagnostic value of antibodies against purified RPA2 protein (A), bRPA2-4 (B), bRPA2-90 (C) and bRPA2-132 (D). Areas under the curve (AUC) were 0.867 (95% CI: 0.798-0.936), 0.812 (95% CI: 0.702-0.813), 0.928 (95% CI: 0.874-0.982) and 0.971 (95% CI: 0.940-1.00), for each antigen. Number in the curves indicate cut-off value of RPA2 Ab level and those in the parentheses indicates specificity (left) and sensitivity (right). Dot plot of antibody levels in patients and healthy donors against purified RPA2 protein (E), bRPA2-4 (F), bRPA2-90 (G) and bRPA2-132 (H). The horizontal bar indicates the cut-off value for each antibody level calculated in the ROC analysis. *P < 0.05 by Mann–Whitney U test.