Table 1.
Serum liver and kidney marker profile at 24 and 12 hours
| AP [U/l] | ALT [U/l] | AST [U/l] | Bilirubin [mg/dl] | BUN [mg/dl] | Creatinine [mg/dl] | |
|---|---|---|---|---|---|---|
| 24-hour animals (sham and CLP) | ||||||
| isoflurane-sham | 126(± 20) | 33.8(± 7.6) | 93(± 33) | 0.109(± 0.027) | 38.8(± 14.8) | 0.33(± 0.13) |
| propofol-sham | 367(± 161)*** | 35.6(± 6.1) | 78(± 17) | 0.176(± 0.055)* | 59.4(±12.0) | 0.72(± 0.32) |
| Isoflurane +CLP | 253(± 117)* | 68.5(± 38.7)* | 210(± 177) | 0.208(± 0.089)** | 71.4(± 21.2)* | 0.80(± 0.28)* |
| Sevoflurane + CLP | 232(± 53)** | 59.3(± 24.7)* | 172(± 107) | 0.186(± 0.073)* | 73.1(± 33.0)** | 0.88(± 0.52)** |
| Desflurane + CLP | 262(± 60)*** | 42.1(± 16.1) | 107(± 55) | 0.151(± 0.024) | 66.7(± 17.0)* | 0.86(± 0.38)* |
| 12-hour CLP animals | ||||||
| Isoflurane + CLP | 187(± 46) | 73.6(± 34.3) | 222(± 136) | 0.164(± 0.051) | 58.6(± 12.7) | 0.53(± 0.19) |
| propofol + CLP | 264(± 185)## | 67.3(± 42.2) | 168(± 109) | 0.255(± 0.104)# | 43.3(± 22.4) | 0.85(± 0.47) |
*P <0.05, **P <0.01, ***P <0.001 versus sham-isoflurane; # P <0.05, ## P <0.001 versus isoflurane + CLP 12 hour. ALT, alanine aminotransferase; AP, alkaline phosphatase; AST, aspartate aminotransferase; BUN, blood urea nitrogen; CLP, cecal ligation and puncture.