Table 2.
Serum cytokines at 24 and 12 hours
| TNF-α [pg/ml] | IL-1α [pg/ml] | IL-1β [pg/ml] | IL-6 [ng/ml] | IL-10 [pg/ml] | CXCL2 [ng/ml] | IFN-γ [pg/ml] | HMGB-1 [ng/ml] | |
|---|---|---|---|---|---|---|---|---|
| 24 hour animals (sham and CLP) | ||||||||
| Isoflurane-sham | 22.7(± 14.6) | 13.9(± 9.2) | 143(± 125) | 4(± 3) | 151(± 95) | 0(± 0) | 12.4(± 12.2) | 0.0(± 0.0) |
| Propofol-sham | 88.7(± 55.9)* | 16.7(± 10.3) | 368(± 112) | 46(± 23) | 605(± 265) | 2(± 2) | 79.3(± 119.4) | 0.0(± 0.0) |
| Isoflurane + CLP | 281.9(± 291.3)*** | 94.9(± 124.7) | 510(± 418)* | 220(± 179)*** | 1717(± 1567)*** | 38(± 42)*** | 134.2(± 131.9)* | 13.5(± 22.3) |
| Sevoflurane + CLP | 89.1(± 70.5)* | 30.6(± 29.1) | 459(± 219)** | 65(± 33)** | 774(± 402)** | 15(± 13)*** | 50.5(± 53.3) | 4.0(± 7.2) |
| Desflurane + CLP | 61.8(± 31.0) | 42.9(± 54.5) | 537(± 325)** | 69( 32)** | 781(± 369)** | 24(± 17)*** | 83.4(± 93.6) | 0.0(± 0.0) |
| 12 hour CLP animals | ||||||||
| Isoflurane + CLP | 141.4(± 78.8) | 24.0(± 17.8) | 325(± 217) | 45(± 16) | 267(± 109) | 3(± 3) | 3.6(± 0.0) | 0.0(± 0.1) |
| Propofol + CLP | 549.9(± 440.2) | 165.8(± 196.1)### | 1446(± 954)### | 126(± 117) | 1240(± 1148)# | 41(± 55)# | 541.9(± 567.7)# | 10.1(± 10.7)# |
*P <0.05, **P <0.01, ***P <0.001 versus sham-isoflurane; # P <0.05, ### P <0.001 versus isoflurane + CLP 12 hour. CLP: cecal ligation and puncture; CXCL2: chemokine (c-x-c motif) ligand 2; HMGB-1: high mobility group protein-1; IFN-γ: interferon gamma; IL-1α: interleukin-1alpha; IL-1β: interleukin-1beta; IL-6: interleukin-6; IL-10: interleukin-10; TNF-α: tumor necrosis factor-alpha.