Table 1.
Characteristics of included studies
| Study | Patients | System | Comparator | Weaning success |
|---|---|---|---|---|
| Agarwal, 2013 [29] | 48 adults | ASV | Protocolized: VCV to PSV | Not defined |
| Aghadavoudi, 2012 [20] | 81 adults | ASV | Protocolized: | Not defined |
| SIMV (VC) + PS to CPAP | ||||
| Burns, 2013 [30] | 92 adults | Smartcare/PS | Protocolized: PSV | Not defined although outcomes reported for first and successful extubation |
| Davis, 1989 [21] | 40 adults | MMV | Protocolized: IMV to CPAP | Not defined |
| Dongelmans, 2009 [19] | 128 adults | ASV | Protocolized: PCV to PSV | Tracheal extubation |
| Hendrix, 2006 [22] | 20 adults | Automode | Protocolized: PRVC to PSV | Not defined |
| Jouvet, 2013 [14] | 30 children | Smartcare/PS | Usual care: PSV | No further need for ventilation for 48 hours after extubation |
| Kirakli, 2011 [15] | 97 adults | ASV | Protocolized: | No further need for ventilation for 48 hours after extubation or with a tracheostomy cannula at day 28 |
| AC (VC) to PSV | ||||
| Lellouche, 2006 [23] | 147 adults | Smartcare/PS | Protocolized: PSV or T-piece | Time from inclusion until successful extubation (followed by 72 hours without ventilator support) |
| Liu, 2013 [31] | 39 adults | Smartcare/PS | Protocolized: daily 30 min SBT of CPAP or PSV | 48 hours without reintubation after extubation |
| Petter, 2003 [32] | 34 adults | ASV | Protocolized: SIMV to PSV | Not defined |
| Ramet, 2002 [28] | 18 children | Automode | Protocolized: PRVC to VS | Not defined |
| Rose, 2008 [16] | 102 adults | Smartcare/PS | Usual care: PSV | No further need for ventilation for 48 hours after extubation |
| Roth, 2001 [24] | 40 adults | Automode | Protocolized: SIMV to PSV | Not defined |
| Schädler, 2012 [17] | 300 adults | Smartcare/PS | Protocolized: PSV | Not defined though outcomes reported for first and successful extubation |
| Stahl, 2009 [33] | 60 adults | Smartcare/PS | Usual care: PSV | Measured reintubation frequency within 48 hours of extubation |
| Strickland, 1993 [25] | 17 adults | Non-commercial system | Usual care: SIMV to PSV/CPAP | Not defined |
| Sulzer, 2001 [34] | 36 adults | ASV | Protocolized: SIMV to PSV | Not defined |
| Taniguchi, 2009 [26] | 106 adults | MRV | Protocolized: PCV to PSV | Not defined |
| Walkey [27] | 33 adults | Smartcare/PS | Usual care: A/C to PSV | No further need for ventilation for 48 hours after extubation |
| Xirouchaki, 2008 [18] | 208 adults | PAV+ | Protocolized: PSV | Not defined |
ASV, adaptive support ventilation; CPAP, continuous positive airway pressure; IMV, intermittent mandatory ventilation; MRV, minute respiratory volume; PAV+, proportional assist ventilation; PRVC, pressure regulated volume control; PSV, pressure support ventilation; SBT, spontaneous breathing trial; SIMV, synchronized intermittent mandatory ventilation; VS, volume support.