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JAK2 and JMJDC2 cooperate in the epigenetic deregulation of oncogenes. Amplification of 9p24 increases the copy number of both JAK2 and JMJD2C, both of which modify histone H3 tails and impede the recruitment of the heterochromatin protein HP1a. The resulting active chromatin structure facilitates the expression of MYC, and perhaps JAK2, JMJD2C, and IL4R. Adapted with permission from [31].
