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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Trends Cell Biol. 2015 Jan 21;25(3):171–184. doi: 10.1016/j.tcb.2014.12.005

Figure I. IQGAP1 domain structure.

Figure I

Mammalian IQGAPs contain several domains that mediate protein-protein interactions. Though many of these domains are found in other proteins, the binding partners for IQGAPs are often unique. The five domains in IQGAP1 are the calponin homology domain (CHD), WW domain, IQ domain (which contains four tandem IQ motifs), GAP related domain (GRD), and the RasGAP_C-terminus (RGCT) [38, 106]. Each domain has diverse interacting partners. Common interactors are binding proteins expected to interact with the specific domain. Unusual interactors are unexpected binding partners for the type of domain. The RGCT represents a domain known only in IQGAPs, therefore, all interactors for this region can be considered unique to IQGAPs.