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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Nat Cell Biol. 2015 Feb 16;17(3):311–321. doi: 10.1038/ncb3110

Figure 3. ADAR1 expression leads to decreased melanoma tumor growth and metastasis.

Figure 3

(A) Effect of ADAR1 silencing in SB2 cells on subcutaneous tumor growth. ADAR1 silencing led to a significant increase in tumor growth, *p<0.05 (n=10 mice in each group. Two-tailed Student t-test; error bars represent s.d.). (B) Effect of ADAR1 silencing on metastatic potential of melanoma cells. An increase in experimental lung metastasis was observed in mice injected with ADAR1-silenced SB2 cells as compared to NT shRNA injected control mice, *p<0.01 (n=7 mice in each group. Statistical significance was determined by two-tailed Student t-test; error bars represent s.d.). (C) Effect of ADAR1 overexpression in C8161 cells on subcutaneous tumor growth. ADAR1 overexpression led to a significant decrease in tumor growth, *p<0.05 (n=10 mice in each group. Two-tailed Student t-test; error bars represent s.d.). (D) Effect of ADAR1 overexpression on metastatic potential of melanoma cells. A significant decrease in experimental lung metastasis was observed in mice injected with ADAR1 overexpressing C8161 cells as compared to empty vector injected control mice, *p<0.01 (Empty vector, n=9 mice; ADAR1 OE, n=7 mice). Statistical significance by two-tailed Student t-test; error bars represent s.d..