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. Author manuscript; available in PMC: 2016 Mar 19.
Published in final edited form as: Neuroscience. 2015 Jan 14;289:289–299. doi: 10.1016/j.neuroscience.2015.01.003

Figure 6. Glial activation is reduced by modulating ATXN1 expression.

Figure 6

ATXN1 expression was turned off in the conditional cATXN1[30Q] -D776 mice at 6 weeks of age. Cerebellar sections from 12 weeks old untreated mice (N = 3, 12 weeks on –continuous expression of mutant ATXN1) or treated mice (N = 6, 6 weeks gene on, and 6 weeks gene off) were stained for Iba1 (a representative image) and GFAP. b Number of Iba1+ microglia in cerebellar cortex c GFAP intensity. d. mRNA levels of TNFα in the cerebella of untreated or DOX treated cATXN1[30Q]-D776 mice. Student's t-test P values are shown with all the histograms. Error bars represent SEM.